Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications
نویسندگان
چکیده
منابع مشابه
Processes of Fibrogenesis in Glomerular Nephropathies
Progressive renal disease is associated with the development of fibrosing lesions in the glomerulusglomerulosclerosis, and in the interstitiuminterstitial fibrosis. The mechanisms involved in this processes are shared by the inflammatory cells and the resident cells: glomerular mesangial cell, interstitial fibroblast, tubular epithelial cell and vascular smooth muscle cell. These resident cells...
متن کاملI. PATHOPHYSIOLOGY OF GLOMERULAR NEPHROPATHIES – Definition, classification
2. BASAL membrane (BM) consists of 3 layers (lamina rara interna, lamina densa and lamina rara externa) contains 4 major components: laminin, type IV collagen, nidogen and heparan sulfate-type proteoglycans (the latter gives the negative charge of the BM) achieves an effective barrier for negatively charged large-molecular-weight proteins (> 69 kDa, > 8 nm diameter) and for albumins (GM =...
متن کاملAcute and chronic toxic nephropathies.
Toxic nephropathies manifest morphologically as glomerulonephritides, vasculitides, tubular necrosis, and acute or chronic tubulointerstitial disease. The most common toxicity is acute interstitial nephritis owing to hypersensitivity. However, focal segmental glomerulosclerosis and necrotizing angiitis secondary to heroin abuse, membranous glomerulopathy owing to gold, penicillamine and captopr...
متن کاملCLINICAL CASE Nephropathies with pattern of structural alterations of the glomerular basement membrane: Case study
a Specialist in Anatomical Pathology, High Speciality Postgraduate in Nephrology of Hospital General de México ‘‘Dr. Eduardo Liceaga’’, Mexico City, Mexico b Specialist in Anatomical Pathology, Surgical Pathology Department of Hospital General de México ‘‘Dr. Eduardo Liceaga’’, Mexico City, Mexico c Surgical Pathology Department of Instituto Nacional de Cardiología ‘‘Ignacio Chávez’’, Mexico Ci...
متن کاملIn progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.
Progression to end-stage renal failure is the final common pathway of many forms of glomerular disease, independent of the type of initial insult. Progressive glomerulopathies have in common persistently high levels of urinary protein excretion and tubulointerstitial lesions at biopsy. Among the cellular mechanisms that may determine progression regardless of etiology, the traffic of excess pro...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2011
ISSN: 1479-5876
DOI: 10.1186/1479-5876-9-13